837Early Goal Directed Therapy for Acute Bacterial Meningitis in Malawian Adults
نویسندگان
چکیده
Malawian Adults Emma Wall, MBChB, MRCP, DTM&H, MRes; Khumbo Kasambala; Veronica Mlozowa; Malango Msukwa MA; Mavuto Mukaka, PhD; Theresa Allain, FRCP PhD; Mulinda Nyirenda, MMed; Brian Faragher, PhD; Robert Heyderman, PhD; David Lalloo, MB, BS, MD; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi; Adult Emergency and Trauma Centre, Queen Elizabeth Central Hospital, Ministry of Health, Government of Malawi, Blantyre, Malawi
منابع مشابه
Corticosteroids for acute bacterial meningitis.
Death and long-term disabilities are common outcomes of acute bacterial meningitis, especially in developing countries, even when highly effective antibiotic therapy is given. Therefore, improvement in the outcomes of acute bacterial meningitis is unlikely to come from developments in chemotherapy but rather from measures that alleviate the damage done before the causative bacteria are killed. ...
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BACKGROUND Mortality from acute bacterial meningitis (ABM) in sub-Saharan African adults and adolescents exceeds 50%. We tested if Goal Directed Therapy (GDT) was feasible for adults and adolescents with clinically suspected ABM in Malawi. MATERIALS AND METHODS Sequential patient cohorts of adults and adolescents with clinically suspected ABM were recruited in the emergency department of a te...
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OBJECTIVE Bacterial meningitis in sub-Saharan Africa is predominantly caused by Streptococcus pneumoniae, is often associated with HIV co-infection and mortality rates are double those seen in better resourced settings. METHODS To investigate the cause of this excessive mortality we quantified the pneumococcal DNA load and six common pro-inflammatory cytokines in the cerebrospinal fluid (CSF)...
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The sequelae of acute bacterial meningitis in children who were treated with ampicillin or chloramphenicol for seven days during the period khordad 1366 to Ordibehesht 1369 were assessed prospectively. 165 patients (85 boys and 80 girls) ranged in age from five days to 12 years (mean 31.5 months) were studied. Haemophilus influenza type B was isolated in 65 % , Streptococcus pneumoniae in 25% a...
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Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 con...
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